Renal Medulla and Renoprival Hypertension

Renal Medulla and Renoprival Hypertension

• Nephreetomized dogs given sodium parenterally and protein by diet develop acute hypertensive cardiovascular disease.' Protection, against acute renoprival hypertension of this type has been demonstrated for (a) intact renal tissue as exemplified by ureterocaval anastomosis, (b) autoexplanation of whole kidney or renal medulla, and (c) a crude extract of renal medulla. Both medullorenal extrac...

Contribution of the adrenal cortex to renal and renoprival hypertension.

Association of the adrenal cortex with renal hypertension lead to the conclusioa that several mechanisms fare operating. First, hypertension is not, or is poorly sustained in true adrenal failure, and mild failure seems to impair vascular responsiveness. This indicates a permissive function of thme adrenal ill renal hypertension. Furthermore, degrees of renal injury or of hyper(orticoidism whic...

Hypertension and cyclooxygenase-2 inhibitors: target: the renal medulla.

Cyclooxygenase (COX)-inhibiting NSAIDs are widely prescribed to treat arthritis, exerting analgesic and antiinflammatory effects via their capacity to block endogenous prostaglandin synthesis.1,2 Unfortunately, their widespread use has been associated with an increased risk of developing hypertension,3,4 and clinical experience with COX-2 selective inhibitors suggests they similarly predispose ...

CONFERENCE on mechanism of protective action of kidney and relation of renoprival to chronic renal hypertension.

Sodium Gradient and Renoprival Hypertension in the Rat

Following uephrectomy in the rat blood pressure rises while the extracellular fluid volume increases, sodium concentration falls and potassium rises. These changes (without the potassium rise) can be mimicked by simple hyperosmotic loading while the reverse can bo induced by dehydration. The rise in blood pressure is not due to either expansion of the extracellular space or the fall in sodium c...